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Joseph J LoTurco, Ph.D.
Professor Physiology and Neurobiology
University of Connecticut


Postions Held:
1992 Post doctoral Fellow, Department of Genetics, Harvard Medical School
1994 Research Associate, Howard Hughes Medical Institute, Harvard Medical School, Department of Genetics
1994 Assistant Professor, University of Connecticut, Department of Physiology and Neurobiology
2000 Associate Professor, University of Connecticut, Department of Physiology and Neurobiology
2005 Professor, University of Connecticut, Department of Physiology and Neurobiology

Honors, Fellowships, and Service
1984 Graduated with Highest Honors, Williams College
1992-1994 National Research Service Award Postdoctoral Fellowship
1995 Klingenstein Fellow in the Neurosciences
2001 Visiting Professor of General Physiology and Biophysics, University of Ferrara.
2003-2005 Chair , FO3B NIH Fellowship study section panel
2004- Chair, University of Conencticut IACUC
2005- Member of Developmental Brain Disorders (DBD) study section.


  1. Lewis, J.L., J.J. Lo Turco, and P.R. Solomon, Lesions of the middle cerebellar peduncle disrupt acquisition and retention of the rabbit's classically conditioned nictitating membrane response. Behav Neurosci, 1987. 101(2): p. 151-7.

  2. Bank, B., J.J. LoTurco, and D.L. Alkon, Learning-induced activation of protein kinase C. A molecular memory trace. Mol Neurobiol, 1989. 3(1-2): p. 55-70.

  3. Blanton, M.G., J.J. Lo Turco, and A.R. Kriegstein, Whole cell recording from neurons in slices of reptilian and mammalian cerebral cortex. J Neurosci Methods, 1989. 30(3): p. 203-10.

  4. Coulter, D.A., et al., Classical conditioning reduces amplitude and duration of calcium-dependent afterhyperpolarization in rabbit hippocampal pyramidal cells. J Neurophysiol, 1989. 61(5): p. 971-81.

  5. Blanton, M.G., J.J. Lo Turco, and A.R. Kriegstein, Endogenous neurotransmitter activates N-methyl-D-aspartate receptors on differentiating neurons in embryonic cortex. Proc Natl Acad Sci U S A, 1990. 87(20): p. 8027-30.

  6. LoTurco, J.J., I. Mody, and A.R. Kriegstein, Differential activation of glutamate receptors by spontaneously released transmitter in slices of neocortex. Neurosci Lett, 1990. 114(3): p. 265-71.

  7. Lo Turco, J.J. and A.R. Kriegstein, Clusters of coupled neuroblasts in embryonic neocortex. Science, 1991. 252(5005): p. 563-6.

  8. LoTurco, J.J., M.G. Blanton, and A.R. Kriegstein, Initial expression and endogenous activation of NMDA channels in early neocortical development. J Neurosci, 1991. 11(3): p. 792-9.

  9. Altshuler, D., et al., Taurine promotes the differentiation of a vertebrate retinal cell type in vitro. Development, 1993. 119(4): p. 1317-28.

  10. LoTurco, J.J., et al., GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis. Neuron, 1995. 15(6): p. 1287-98.

  11. Bittman, K., et al., Cell coupling and uncoupling in the ventricular zone of developing neocortex. J Neurosci, 1997. 17(18): p. 7037-44.

  12. Cogswell, C.A., et al., A gene essential to brain growth and development maps to the distal arm of rat chromosome 12. Neurosci Lett, 1998. 251(1): p. 5-8.

  13. Immke, D., et al., Influence of non-P region domains on selectivity filter properties in voltage-gated K+ channels. Receptors Channels, 1998. 6(3): p. 179-88.

  14. Kiss, L., et al., The interaction of Na+ and K+ in voltage-gated potassium channels. Evidence for cation binding sites of different affinity. J Gen Physiol, 1998. 111(2): p. 195-206.

  15. Li, W., C.A. Cogswell, and J.J. LoTurco, Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP. J Neurosci, 1998. 18(21): p. 8853-62.

  16. Nisenbaum, L.K., et al., Early patterning of prelimbic cortical axons to the striatal patch compartment in the neonatal mouse. Dev Neurosci, 1998. 20(2-3): p. 113-24.

  17. Bittman, K.S. and J.J. LoTurco, Differential regulation of connexin 26 and 43 in murine neocortical precursors. Cereb Cortex, 1999. 9(2): p. 188-95.

  18. Kiss, L., J. LoTurco, and S.J. Korn, Contribution of the selectivity filter to inactivation in potassium channels. Biophys J, 1999. 76(1 Pt 1): p. 253-63.

  19. Sarkisian, M.R., et al., Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development. Epilepsia, 1999. 40(4): p. 394-400.

  20. Chang, S.L., J.J. LoTurco, and L.K. Nisenbaum, In vitro biocytin injection into perinatal mouse brain: a method for tract tracing in developing tissue. J Neurosci Methods, 2000. 97(1): p. 1-6.

  21. Frenkel, M., et al., Neocortical ectopias are associated with attenuated neurophysiological responses to rapidly changing auditory stimuli. Neuroreport, 2000. 11(3): p. 575-9.

  22. Li, W. and J.J. LoTurco, Noggin is a negative regulator of neuronal differentiation in developing neocortex. Dev Neurosci, 2000. 22(1-2): p. 68-73.

  23. LoTurco, J.J., Neural circuits in the 21st century: synaptic networks of neurons and glia. Proc Natl Acad Sci U S A, 2000. 97(15): p. 8196-7.

  24. Roberts, M.R., et al., The flathead mutation causes CNS-specific developmental abnormalities and apoptosis. J Neurosci, 2000. 20(6): p. 2295-306.

  25. Gabel, L.A. and J.J. LoTurco, Electrophysiological and morphological characterization of neurons within neocortical ectopias. J Neurophysiol, 2001. 85(2): p. 495-505.

  26. Peiffer, A.M., et al., Impaired detection of variable duration embedded tones in ectopic NZB/BINJ mice. Neuroreport, 2001. 12(13): p. 2875-9.

  27. Sarkisian, M.R., et al., Altered interneuron development in the cerebral cortex of the flathead mutant. Cereb Cortex, 2001. 11(8): p. 734-43.

  28. Gabel, L.A. and J.J. LoTurco, Layer I ectopias and increased excitability in murine neocortex. J Neurophysiol, 2002. 87(5): p. 2471-9.

  29. Sarkisian, M.R., et al., Citron-kinase, a protein essential to cytokinesis in neuronal progenitors, is deleted in the flathead mutant rat. J Neurosci, 2002. 22(8): p. RC217.

  30. Bai, J., et al., RNAi reveals doublecortin is required for radial migration in rat neocortex. Nat Neurosci, 2003. 6(12): p. 1277-83.

  31. Belluzzi, O., et al., Electrophysiological differentiation of new neurons in the olfactory bulb. J Neurosci, 2003.23(32): p. 10411-8.

  32. LoTurco, J.J., et al., Citron kinase is a regulator of mitosis and neurogenic cytokinesis in the neocortical ventricular zone. Cereb Cortex, 2003. 13(6): p. 588-91.

  33. LoTurco, J., Doublecortin and a tale of two serines. Neuron, 2004. 41(2): p. 175-7.

  34. Li, R.W., et al., Disruption of postsynaptic GABA receptor clusters leads to decreased GABAergic innervation of pyramidal neurons. J Neurochem, 2005. 95(3): p. 756-70.

  35. Pignatelli, A., et al., Functional Properties of Adult-born Juxtaglomerular Cells in the Mammalian Olfactory Bulb. Chem Senses, 2005. 30 Suppl 1: p. i119-i120.

  36. Meng, H., et al., DCDC2 is associated with reading disability and modulates neuronal development in the brain. Proc Natl Acad Sci U S A, 2005. 102(47): p. 17053-8.

  37. Ramos, R.L., J. Bai, and J.J. Loturco, Heterotopia Formation in Rat but Not Mouse Neocortex after RNA Interference Knockdown of DCX. Cereb Cortex, 2006.

  38. Ackman, J.B. and J.J. Loturco, The potential of endogenous neuronal replacement in developing cerebral cortex following hypoxic injury. Exp Neurol, 2006.

  39. Paracchini, S., et al., The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration. Hum Mol Genet, 2006. 15(10): p. 1659-66.

  40. LoTurco, J.J. and Bai, J. The multipolar mode and neuronal migration disorders.
    Trends in Neuroscience (2006). 27(7) 407.

  41. Galaburda AM, LoTurco J, Ramus F, Fitch RH, Rosen GD.From genes to behavior in developmental dyslexia. Nat Neurosci. 2006 Oct;9(10):1213-7. Review.

  42. Ackman JB, Siddiqi F, Walikonis RS, LoTurco JJ. Fusion of microglia with pyramidal neurons after retroviral infection. J Neurosci. 2006 Nov 1;26(44):11413-22.

  43. Wang Y, Paramasivam M, Thomas A, Bai J, Kaminen-Ahola N, Kere J, Voskuil J, Rosen GD, Galaburda AM, Loturco JJ. DYX1C1 functions in neuronal migration in developing neocortex. Neuroscience. 2006 Dec 1;143(2):515-22. Epub 2006 Sep 20.

  44. Rosen GD, Bai J, Wang Y, Fiondella CG, Threlkeld SW, Loturco JJ, Galaburda AM. Disruption of Neuronal Migration by RNAi of Dyx1c1 Results in Neocortical and Hippocampal Malformations. Cereb Cortex. 2007, 17(11):2562-2572.

  45. Ackman, J., Raddy L. Ramos, Matthew R. Sarkisian, and Joseph J. LoTurco. Citron Kinase is Required for Postnatal Neurogenesis in the Hippocampus. Dev Neurosci. 2007;29(1-2):113-23.

  46. Threlkeld SW, McClure MM, Bai J, Wang Y, Loturco JJ, Rosen GD, Fitch RH. Developmental disruptions and behavioral impairments in rats following in utero RNAi of Dyx1c1. Brain Res Bull. 2007 Mar 15;71(5):508-14. Epub 2006 Dec 5.

  47. Paramasivam, M., Y.J. Chang, and J.J. Loturco, ASPM and Citron Kinase Co-Localize to the Midbody Ring During Cytokinesis. Cell Cycle, 2007. 6(13).

  48. Young-Pearse TL, Bai J, Chang R, Zheng JB, LoTurco JJ, Selkoe DJ. A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference. J Neurosci 2007;27:14459-14469.

  49. Bai J, Ramos RL, Paramasivam M, Siddiqi F, Ackman JB, LoTurco JJ (2008) The role of DCX and LIS1 in migration through the lateral cortical stream of developing forebrain. Dev Neurosci 30:144-156.

  50. Burbridge TJ, Wang Y, Volz AJ, Peschansky VJ, Lisann L, Galaburda AM, LoTurco JJ, Rosen GD. Postnatal analysis of the effect of embryonic knockdown and overexpression of candidate dyslexia susceptibility gene homolog Dcdc2 in the rat. Neuroscience. 2008; 152(3):723-733.

  51. LoTurco JJ, Kriegstein AR Manipulating midbrain stem cell self-renewal. Cell Stem Cell. 2008; 2:405-406.

  52. Manent JB, Wang Y, Chang Y, Paramasivam M, LoTurco JJ (2009) Dcx reexpression reduces subcortical band heterotopia and seizure threshold in an animal model of neuronal migration disorder. Nat Med 15:84-90.

    © 2008. Page created by Alena Rosen and maintained by Glenn Rosen. Last updated February, 2009.